Get familiar with the Microsoft Accessibility Checker [official guide].
Use it as a guide when designing Word, Excel, and PowerPoint Files.

• Name worksheets.
• Use cell A1 as the title of the spreadsheet.
• Data formatted as tables needs descriptive headers.
• Name the table.
• Use chart titles and labels.
• Remove blank rows/columns.
• Empty cells include “no data.”
• Alt text for images, charts, and tables.
• Use alt text in cells where color is the only way to convey meaning (conditional formatting.)
• Formatting emphasis, ALL CAPS and strikethrough not perceivable to some users.
• Link to other sheets for keyboard-only users.
• Adjust text wrapping and column width to improve readability of all cell data.
• Avoid hiding rows and columns.
• Alert users with text where frozen panes are active.

Excel Resources

• Make Excel Spreadsheets Accessible [official guide]